最新帝斯曼公司介绍PPT课件 32页

'帝斯曼公司介绍 IntroductionofDr.ArnoldGloor(Switzerland)介绍阿诺.阁老(瑞士)MasterofChemistryofFederalTechnicalUniversity瑞士联邦工业大学的硕士研究生1993F.Hoffman-LaRocheAG,Pharmadiv.R&D工作于霍夫曼罗氏公司,原料药研发部1996F.Hoffman-LaRocheAG,Vitamindiv.R&D工作于霍夫曼罗氏公司,维生素研发部2003DSMacquisitionofVitaminDiv,Marketingdept.StartingAromachemicalbusiness.DSM购并了维他命部门,工作于市场部,开始从事合成香料销售业务.1 DSMNutritionalProducts帝斯曼营养产品LargestVitaminandCarotenoidproducerintheworld世界上最大的维生素和类胡罗卜素的生产商ProducingVitaminssince1933从1933年开始生产维生素ProducingAromaChemicalssince1964从1964年开始生产合成香料LargeScaleProduction产量巨大8 DSMNutritionalProducts帝斯曼营养产品Globalnetworkofdedicatedplants全球生产自有基地网络ManufacturingSitesBelvidereArachidonicacidFreeportß-CaroteneDalryVitCCalpanOctabaseVillage-NeufCanthaxanthinApoesterApocarotenalLycopeneBiotinGrenzachVitB1,B2,B6,D3BiotinIntermediatesLaldenAromachemicalsIntermediatesforVitA,ETienenCitricacidSisselnVitA,E,K1FolicacidAstaxanthinAromachemicalsIntermediatesXinghuo,Gonglu,WuxiVitB6,ATeavigoCitricacidß-胡罗卜素花生四烯酸柠檬酸维生素C卡尔班辛烷基维生素A,E,K叶酸虾青素合成香料中间体维生素A,B6茶维力柠檬酸维生素B1,2,6,D3维生素H中间体角黄素阿朴酯阿朴胡萝卜素醛蕃茄红色素维生素H合成香料维生素A,E的中间体9 AromaChemicals合成香料产品LINALOOLFAMILY芳樟醇家族LINALOOL芳樟醇LINALYLACETATE乙酸芳樟酯TETRAHYDROLINALOOL四氢芳樟醇TETRAHYDROLINALYLACETATE乙酸四氢芳樟酯ETHYLLINALOOL乙基芳樟醇ETHYLLINALYLACETATE乙酸乙基芳樟酯IONONES紫罗兰酮BETA-IONONE乙位紫罗兰酮ISONALINE(Methyl-Ionone)异甲基紫罗兰酮BENZOIDS苯甲醛下游CINNAMICALDEHYDE苯甲醛CINNAMICALCOHOL桂醛BENZYLALCOHOL苯甲醇PHENYLPROPANOL苯丙醇SPECIALITIES小原料NEROLIDOL橙花叔醇GERANYLACETONE香叶基丙酮METHYLHEPTENONE甲基庚烯桐ISOPHYTOL异植物醇10 Whenitstarted起源HydroPower水能11 CheapElectricity廉价的电能GrandeDixence,SwitzerlandWhenitstarted起源Electricity电能LonzaAG龙沙化学1897AcetylenefromCa-CarbideDiketene,Ammonia从电石制乙炔.双烯酮,氨水AluminiumIndustrieAG铝业公司1905Refining提炼CIBAAG汽巴精化1898Electrochemistry,Indigo电化学英迪格ElectricRailNetwork电器铁路网1890CourtesyLonzaAGCourtesyABBLtd12 Atthebeginningofthe20thcentury,theperfumeindustryneededcheaparomachemicalsforthegrowingdemand.20世纪初,香料工业开始需要大量廉价的合成原料来应对日益增长的需求.Naturalsourcesweretooexpensive.天然来源的香料十分昂贵.Alotofresearchstartedtodevelopchemicalprocessesforthemanufacturingofaromachemicalsbasedonnaphta.许多针对以液化石油汽为基础的化学合成香原料研究开始进行.1919thesynthesisofLinaloolbasedonAcetylenewasdiscoveredandlaterindustrialized.1919年,以乙炔为起始原料的芳樟醇被开发出来,随后工业化成功.TodayLinaloolisstillproducedaccordingthesameprinciples.Later,theaccesstootheraromachemicalswasdevelopedbasedonAcetylene今天,芳樟醇还是用同样的工艺生产,后续,以乙炔为起始原料的其它香原料陆续出现.13 Whenitstarted起源:SynthesisofAromachemicals合成香料Prof.LeopoldRuzickaandstudents1937,ETHZurich,Switzerlandontherightside:Dr.TadeusReichenstein(courtesyLibraryETHZ)卢兹卡教授和他的学生,1937年摄于瑞士苏黎士.最右边是塔杜.雷切斯坦博士14 Whenitstarted起源FirstLinaloolSynthesis芳樟醇最早的合成路线L.RuzickaandV.Fornasier,1919甲基庚烯酮去氢芳樟醇芳樟醇L.卢兹卡和V.富纳什,1919年的合成路线15 Whenitstarted起源:Ruzickafundamentalresearch卢兹卡的基础研究ImportantResearchTopics研究的里程碑:1916Fenchone葑酮1919Linalool,Beta-Collidine芳樟醇,乙位-三甲基吡啶1921Nerolidol,Farnesol,Irone叔花叔醇,金合欢醇,鸢尾酮Musk,Civetone,Muscone麝香,灵猫酮,麝香酮1930MaleSexHormones雄性荷尔蒙1937Triterpenes,Steroids三萜烯,类固醇IndustrialCollaborations工业上的合作者Haarmann&Reimer哈默及雷默Chuit,Naef&Firmenich徐特,纳夫及芬美意Ciba汽巴精化RockefellerFoundation勒克菲勒基金courtesyLibraryETHZ16 METHYLHEPTENONE甲基庚烯酮Dehydrolinalool去氢芳樟醇LINALYLACETATETH-LINALYLACETATE乙酸芳樟酯,乙酸四氢芳樟酯LINALOOLGERANYLACETONENEROLIDOL香叶基丙酮,橙花叔醇DIHYDROLINALOOLTETRAHYDROLINALOOL二氢芳樟醇,四氢芳樟醇Whenitstarted起源:SynthesisofAromachemicals合成香料Linalool芳樟醇:Ruzicka卢兹卡,1919,Dehydrolinalool去氢芳樟醇Nerolidol橙花叔醇:Ruzicka卢兹卡,1923,GeranylAcetone香叶基丙酮Geranylacetone香叶基丙酮Caroll卡罗,1940,Linalool芳樟醇Kimel基米,1943,Linalool芳樟醇Saucy绍西,1960–70Linalool芳樟醇70Linalylacetate乙酸芳樟醇RocheDevelopment由罗氏开发17 Asideofthedevelopmentinaromachemicals,Vitaminswerediscoveredandidentified.除了合成香料的发展以外,维生素也被发现并鉴定出来.ThebiologicaleffectsofVitaminswerestudied.对维生素进行了生物学研究.Maininventorswere主要的发明者是PaulKarrer,Switzerland保罗卡瑞,瑞士RichardKuhn,Germany里查德奎恩,德国F.Hoffmann–LaRochestartedtodevelopthefirstchemicalsynthesisforVitaminEandAF.霍夫曼–罗氏公司开发了第一条维生素A和E的合成路线.ThedevelopmentswereleadbyOttoIssler(F.Hoffmann-LaRoche)开发由奥特依斯乐领导(霍夫曼.曼氏公司)ThechemicalprocessesweredevelopedbasedonAcetylene化学合成路线是以乙炔为起始原料.18 RichardKuhn里查德奎恩PaulKarrer保罗卡瑞HansvonEuler-Chelpin汉斯冯乌乐-切乐平HugoTheorel雨果特瑞lOttoWarburg奥特沃伯格OttoIsler奥特依斯乐VitaminE1940VitaminA1945F.Hoffmann-LaRocheAGF.霍夫曼-罗氏公司Whenitstarted起源:StructuralIdentificationandIsolationofVitamins结构式鉴定以及维生素分离19 Whenitstarted起源IononesynthesisstartingfromAcetoneandAcetylene紫罗兰酮的合成起源于乙炔,丙酮路线METHYLHEPTENONE甲基庚烯酮Dehydrolinalool去氢芳樟醇PSEUDOIONONE假性紫罗兰酮METHYLPSEUSOIONONE甲基假性紫罗兰酮METHYLGAMMAIONONE异甲基紫罗兰酮BETAIONONE乙位紫罗兰酮>>维生素A,VitAIONONESFORCAROTENOIDS用于生产类胡罗卜素的紫罗兰酮ISOPHYTOL异植物醇>>维生素E,VitEVitAdownstreamintermediates维生素A的下游中间体Lindlar林德乐1947Beta-Ionone乙位紫罗兰酮Isler依斯乐1947,Pseudoionone假性紫罗兰酮Pseudoionone假性紫罗兰酮Roche罗氏1967,(Kimel基米1943)Saucy绍西–Marbet马贝特1971Methylpseudoionone甲基假性紫罗兰酮Saucy绍西–Marbet马贝特1958Dehydrolinalool去氢芳樟醇20 TheheadsofResearchofGivaudanandF.Hoffmann-laRochedecidedtostartaprojecttocombinethechemicalprocessesofGivaudanandF.HoffmannlaRoche.奇华顿和霍夫曼罗氏的开发的领导者决定把奇华顿和罗氏的化学品生产合并在一起.BostchemicalconceptsarebasedonAcetyleneandDeyhdrolinaloolaskeycompounds.所有的生产都是以乙炔为起始原料的,去氢芳樟醇是一个关键的中间体.Jointlargescalemanufacturingofaromachemicalsandvitaminsgeneratedthebestcostposition.把产能可观的合成香料和维他命合并起来,形成了成本上的巨大优势.21 ModernManufaturingConcept现代的生产理念TerpeneTree-FragranceandIntermediatesforVitamins萜类产品树–香原料和维生素中间体METHYLHEPTENONE甲基庚烯酮Dehydrolinalool去氢芳樟醇LINALYLACETATE乙酸芳樟醇TH-LINALYLACETATE乙酸四氢芳樟酯PSEUDOIONONE假性紫罗兰酮LINALOOL芳樟醇GERANYLACETONE香叶基丙酮NEROLIDOL橙花叔醇DIHYDROLINALOOL去氢芳樟醇TETRAHYDROLINALOOL四氢芳樟醇METHYLPSEUSOIONONE甲基假性紫罗兰酮METHYLGAMMAIONONE异甲基紫罗兰酮BETAIONONE乙位紫罗兰酮IONONESFORCAROTENOIDS用于类固醇生产的紫罗兰酮HEXAHYDROPSEUDOIONONE六氢假性紫罗兰酮ISOPHYTOL异植物醇22 ModernManufacturingConcept现代生产理念Hoffmann-LaRochesetup霍夫曼罗氏的建立1964AcquisitionofGivaudanbyF.Hoffmann–LaRocheAG奇华顿被罗氏所收购1965FoundationofRocheTeranolAG(since2003DSMLalden)andsiteSisseln罗氏特兰公司成立(雷登基地.被帝斯曼2003购并),以及士森恩生产基地1966StartupofNaphtaCracker液化石油汽裂解装置建立F.Hoffmann-LaRocheAG霍夫曼.罗氏公司VitaminDiv.维生素部门Site基地Lalden雷登Frag.&Flav.Div.香料部Basel巴塞尔Sisseln士森恩GivaudanGeneva奇华顿日内瓦PharmaDiv.原料药部DiagnosticDiv.诊断部23 ModernManufacturingConcept现代生产理念SpinOffsAcquisitions分拆与购并1964AcquisitionofGivaudanbyF.Hoffmann–LaRocheAG奇华顿被霍夫曼罗氏公司所购并1965FoundationofRocheplantinLalden(since2003DSMLalden)罗氏的雷登生产基地落成(2003年被帝斯曼所购并)1966StartupofNaphtaCracker开始液体石油汽裂解2000SpinoffGivaudanand2003AcquisitionofRocheVitmaminsbyDSM奇华顿被分拆出来独立,2003年帝斯曼购并了罗氏的维他命部门DSMSiteLalden帝斯曼的雷登基地GivaudanS.A.奇华顿Flavour&Fragrance香精香料DSMSiteSisseln帝斯曼的士森恩基地Pharma原料药Diagnostic诊断DSM帝斯曼Roche罗氏F&FIndustry香精香料工业Aromachemicals合成香料24 IntermediatePlantDSMLalden,Switzerland帝斯曼在瑞士雷登的中间体工厂AromaChemicalsandIntermediatesforVitaminsandCarotenoids生产合成香料与维生素及类胡萝卜素中间体Founded1965成立于1965年25 VitaminPlant,DSMSisseln,Switzerland帝斯曼在瑞士士森恩的生产工厂BetaIonone,MethylGammaIonone乙位紫罗兰酮及异甲基紫罗兰酮Founded1965成立于1965年◄Rhine莱茵河◄GermanyBlackForest德国黑森林Switzerland瑞士26 ModernManufacturingConcept现代生产理念GeographicLocations地理位置DSMSiteLaldenLonzaAG帝斯曼的雷登工厂DSMSiteSisseln帝斯曼土森恩基地Geneva日内瓦Basel巴塞尔Headquarter总部DSMNutritionalProductsLtd帝斯曼营养产品有限公司Kaiseraugst凯瑟奥古斯特27 PortfolioAromaChemicals合成香料简介28 PortfolioofAromaChemiclasofDSMNutritionalProductsasoftoday当前帝斯曼营养产品的合成香料产品线LINALOOLFAMILY芳樟醇家族LINALOOL芳樟醇LINALYLACETATE乙酸芳樟酯TETRAHYDROLINALOOL四氢芳樟醇TETRAHYDROLINALYLACETATE乙酸四氢芳樟酯ETHYLLINALOOL乙基芳樟醇ETHYLLINALYLACETATE乙酸乙基芳樟酯IONONES紫罗兰酮BETA-IONONE乙位紫罗兰酮ISONALINE(Methyl-Ionone)异甲基紫罗兰酮BENZOIDS苯甲醛下游CINNAMICALDEHYDE苯甲醛CINNAMICALCOHOL桂醛BENZYLALCOHOL苯甲醇PHENYLPROPANOL苯丙醇SPECIALITIES小原料NEROLIDOL橙花叔醇GERANYLACETONE香叶基丙酮METHYLHEPTENONE甲基庚烯桐ISOPHYTOL异植物醇29 Thankyouforyourattention感谢您参加本次演示会30 结束语谢谢大家聆听！！！31'